OR72. The relationship between diabetes mellitus and homocysteine level in peripheral arterial disease population in mataram city

Abstract

Abstract Background Peripheral Arterial Disease (PAD) is partial or total blockage of blood vessel caused by occlusive atherosclerosis especially in lower extremity. Hyperhomocysteinemia had been used as a biomarker of cardiovascular disease such atherosclerosis formation process. Previous study have reported higher incidence of homocysteine level in patient with Diabetes Mellitus (DM) type 2. However, data on homocysteine level in PAD patient with DM type 2 is limited. Therefore, this study aim to investigate the comparation between DM and homocysteine level in PAD patient in Mataram City. Methods and Results This study is a cross sectional study conducted at Siti Hajar Islamic Hospital in Mataram City. The sample was patients with PAD with an ankle brachial index score <0.90 and DM type 2. The outcome of this study was homocysteine level on DM PAD patient and non-DM PAD patient. Data analysis using the unpaired T test. fifty-two PAD patients in this study, with 75% female (39) and average age of 57.4 years old in this research. The average homocysteine level in PAD patient with DM (5.7±0.9 µmol/L) was significantly higher than those in non-DM PAD patient (4.8±1.0 µmol/L) (p = 0.001). We found that history of hypertension was significantly higher in non-DM PAD patient and ankle brachial index score was significantly lower in DM PAD patient (p = 0.049). Conclusion There is a significant differences of homocysteine level within DM patient compared to non-DM patient.