OR39. High Level of Non-High-Density Lipoprotein Cholesterol Was Associated with Severe Coronary Artery Stenosis in Chronic Coronary Syndrome Patients at Sanglah General Hospital

Abstract

Abstract Aims (1)To prove the association between non-HDL cholesterol level and severity of coronary artery lesions in chronic coronary syndrome (CCS) patients who undergo coronary angiography (2) Determine optimal cutoff value for non-HDL, LDL and TG cholesterol levels that were associated with severe coronary artery lesions in CCS patients. Methods and Results This is an analytic observational study using consecutive sampling technique that was conducted from June to November 2020. The relationship between non-HDL cholesterol and degree of coronary stenosis was assessed using Chi-square test. Of the subjects that were included, 90.3% (65/72) are men, mean age of 59.43 ± 8.9 years. Non HDL-C (cut off 104.5 mg/dL), has area under curve 0.846, sensitivity 80% and specificity 78.1%, (p < 0.001). Bivariate analysis showed that high non-HDL cholesterol was related to the degree of severe coronary stenosis (prevalence ratio of 3.385; CI95% 1.819-6.296, p < 0.001). Multivariate logistic regression analysis showed high non-HDL cholesterol is an independent predictor of severe coronary artery stenosis in CCS patients (OR of 25.8; 95% CI 6,46-103; p < 0.001). Sub-analysis based on lipid fraction showed that high non-HDL cholesterol (> 104.5 mg / dL) had better AUC (0.846), sensitivity (80%) and specificity (78.1%) compared to high LDL (LDL >81 mg/dL with AUC 0.793, p < 0.001/ Se 70%/ Sp 68.8%) and high TG (TG > 132.5 mg/dL with AUC 0.623, p = 0.111/ Se 57.5% / Sp 53.1%). Conclusion High non-HDL cholesterol is independently associated with severe coronary stenosis in CCS patients, while having better association to severe coronary artery stenosis. Optimal cut off point for non-HDL-C, LDL-C and TG were 104.5 mg/dL, 81 mg/dL and 132.5 mg/dL.