OR23. Correlation of Right Ventricular Systolic Function by Right Ventricular Global Longitudinal Strain in Rheumatic Mitral Stenosis compared to Mitral Regurgitation before and after Intervention

Abstract

Abstract Background and Aims Right ventricle systolic dysfunction develop prior to the onset of clinical systemic congestion; thus, early detection is beneficial for both diagnostic and therapeutic value. We aim to asses changes of Right Ventricular Global Longitudinal Strain (RVGLS) in rheumatic mitral valve disease, and assess correlation between Right Ventricular Systolic Pressure (RVSP) and RVGLS before and after intervention. Methods and Results Our study consisted of 21 patients with an established diagnosis of significant MS or MR and normal RV function, who were admitted for either Balloon Mitral Valvulotomy (BMV) or Mitral Valve Replacement (MVR). 2D echocardiography and measurement of RVGLS was obtained from RV-focused A4CH view. Patients were divided into 2 groups: (1) significant MS consists of 11 patients, (2) significant MR consists of 10 patients. Prior to intervention, MS group had significantly lower RVGLS compared to MR group (-11.64 vs. -18.29; p = 0.001). After MVR, the RVGLS of MS group was significantly increased compared to MR group (MS -11.64 to -15.59, p = 0.001 vs. MR -18.29 to -19.39, p = 0.069). Both MS and MR groups showed significant negative correlation between RVSP and RVGLS before and after intervention (r=-0.642; p = 0.002; r=-0.670; p = 0.001). Conclusion Pre-intervention with a background normal RV function, RVGLS was impaired significantly in MS group compared to MR group. Post intervention RVGLS improved significantly in MS group compared to MR group. Both groups showed significant negative correlation between RVSP and RVGLS before and after intervention.