OR20. Correlation between diabetes mellitus and significant in-stent restenosis in patient underwent coronary angiography evaluation

Abstract

Abstract Aims Percutaneous Coronary Intervention (PCI) is a non-surgical invasive intervention with or without stenting performed on coronary heart disease (CHD) patient to improve blood flow of narrowed coronary arteries. One of the complication after PCI is in-stent restenosis (ISR), which is the narrowing of stented segment of coronary artery. Diabetes Mellitus (DM), is characterized by hyperglycemia, has long been known to increase the risk of CHD by 2-4 fold. Condition of hyperglycemia in diabetes has affects on the progression of neointimal hyperplasia (NIH) that progress to ISR. As the number of CHD patients with diabetes mellitus (DM) is expected to increase, so is the risk of ISR incidence in CHD patients with diabetes mellitus (DM) who undergo PCI. Method and Results A retrospective cross-sectional study was conducted using medical records of CHD patients who underwent coronary angiography evaluation between January 2018 and March 2020 at Catheterization Laboratory, Regional General Hospital of West Nusa Tenggara. Significant ISR was defined as diameter of stenosis ≥50% at coronary angiography evaluation. Total subjects were 66 subjects, with 33 DM subjects and 33 non-DM subjects, and ISR was found in 12 and 10 subjects respectively. There was no significant difference on the incidence of ISR between the DM and non-DM groups. Conclusion There was no correlation between DM and ISR, and there was no significant difference in the incidence of ISR between the DM and non-DM group in CHD subjects underwent coronary angiography evaluation.