Abstract
Aim Previous studies have shown an association between HLA and disease processes, such as CLL. The goal of this study was to determine if HLA homozygosity was associated with lymphoma or AML. Methods We analyzed 530 lymphoma and 750 AML patients who were typed for possible stem cell transplant from late 2006 to early 2015. All patients were typed at HLA-A, B, C, DRB1, and DQB1. Control data consisted of 4683 normal subjects whose HLA alleles were imputed from GWAS analysis. Homozygosity was defined as two alleles belonging to the same P-group at any HLA locus. Results 40.6% of the lymphoma patients were homozygous for one or more HLA locus ( p = 0.005), compared to 34.4% of the control subjects and 33.2% of AML patients ( p = 0.562). The HLA-A,B and DQB1 loci appeared to contribute most of the difference in homozygosity. Patients who were diagnosed with lymphoma at an earlier age ( n = 116) had a higher degree of homozygosity (47.4%) than patients >40 years old ( n = 414, 38.6%), although the difference is not statistically significant ( p = 0.11) with this sample size. Conclusions HLA homozygosity, particularly at HLA-A,B and DQB1, is associated with a higher incidence of lymphoma, but not AML. Download full-size image
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