Abstract
Mast cells, key effector cells of allergic and innate immune responses, have recently been reported to be an important source of IL-1s in patients with autoinflammatory conditions such as cryopyrin-associated-periodic-fever syndromes (CAPS). CAPS patients show IL-1beta-driven systemic inflammation together with non-histamine dependent urticarial rash, which are caused by activating mutations of the inflammasome, a multiprotein oligomer responsible for the initiation of inflammatory responses to pathogens.
Highlights
Mast cells, key effector cells of allergic and innate immune responses, have recently been reported to be an important source of IL-1ß in patients with autoinflammatory conditions such as cryopyrin-associated-periodic-fever syndromes (CAPS)
OR11-005 - Mast cells respond to pathogen signals with IL-1ß
To determine if mast cells can produce and release IL-1ß in response to pathogenic signals that target the inflammasomes NLRP3, NLRC4, or AIM2
Summary
Key effector cells of allergic and innate immune responses, have recently been reported to be an important source of IL-1ß in patients with autoinflammatory conditions such as cryopyrin-associated-periodic-fever syndromes (CAPS). OR11-005 - Mast cells respond to pathogen signals with IL-1ß L Kraas1*, O Schmetzer1, K Krause1, E Latz2, M Maurer1 From 7th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID) Lausanne, Switerland.
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