Abstract
Alcohol is known as a neurotoxic material, and can induce the neurodegenesis in the brain. Among the various causes of the cognitive deficiency in the alcohol dependence, the role of corticosteroid can be focused. Recently insulin like growth factor-1(IGF-1) is showed to reflect the status of growth hormone which is under the action of HPA axis. The purpose of this study was to confirm the relations between cognitive function and IGF-1 and investigate the impact of corticosteroid on cognitive function in the alcohol dependence. The participants were 40 alcohol dependence patients. IGF-1. IGF-1 were measured through ELISA We also examined clinical features and the Korean version of Alcohol Dependence Scale(ADS-K). We measured Consortium to Establish a Registry for Alzheimer's Disease(CERAD). And we compared the relationships between many parts of CERAD and IGF-1. Alcohol dependent patients conducted the stable ability in most parts of CERAD. Among the parts of CERAD, only trail making A showed the correlation to IGF-1. Comparing to trail making B, trail making A is assumed to reflect the basic cognition without education and learning. Therefore IGF-1 might play an important role in detecting the decline of more basic cognitive function in alcohol dependence.
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