Abstract
OR-014 Chronic exercise potentiates anorectic effects of leptin in hypothalamic Pomc neurons
Highlights
Chronic imbalance of energy homeostasis leads to obesity and metabolic mellitus, which has developed as a major public health and economic burdens around the world
Previous studies revealed that leptin receptors (LepRs) in arcuate Pomc neurons are required and sufficient for the proper regulation of energy balance and glucose homeostasis, including systemic insulin sensitivity and hepatic glucose production
We aimed to investigate the role of exercise in mediating hypothalamic Pomc neuron activity, anorectic effects of leptin and glucose tolerance as well as insulin sensitivity
Summary
Chronic exercise potentiates anorectic effects of leptin in hypothalamic Pomc neurons Zhao Gao1,3,Xingping Yang2,Yuan Zhang1,Qin Xu3 1.GuangDong provincial research insititute of sports science 2.The First Affiliated Hospital of GuangDong Pharmaceutical University
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