Abstract
We investigated the effect of Opuntia humifusa (O. humifusa) supplementation on bone density and related hormone secretion in growing male rats. Sixteen six-week-old male Sprague-Dawley rats were randomly divided into two groups; control diet group (CG, n = 8), and experimental diet group (EG, n = 8). The rats in the CG were given a control diet and those in the EG were given 5% O. humifusa added to the control diet for eight weeks. The serum OC level of the EG was significantly higher than that of the CG, and the serum parathyroid hormone (PTH) level of EG was significantly lower than that of the CG. In addition, the femoral and tibial BMD of the EG were significantly higher values than those of the CG, and the tibial BMC of the EG was significantly higher than that of the CG. These results suggest that O. humifusa supplementation has a positive effect on bone density by suppressing PTH and increasing the OC level in growing male rats.
Highlights
Osteoporosis is one of the most common metabolic bone diseases, and it increases the risk of fracture by reducing bone strength [1]
Mg2+ deficiency is well known as a potential risk factor of osteoporosis [9], as well as a cause of impaired parathyroid hormone (PTH) secretion, which in turn dysregulates Ca2+
In this study, we investigated the effects of O. humifusa supplementation on bone-related hormones and bone metabolism
Summary
Osteoporosis is one of the most common metabolic bone diseases, and it increases the risk of fracture by reducing bone strength [1]. Previous studies have suggested that the bone mass is relatively decreased and at a higher risk of fracture in obese children because the bone mineral density (BMD) and bone mineral content (BMC) are lower in obese children than in normal children [3,4]. Sufficient mineral intake in the growth period, such as calcium (Ca2+) [5] and magnesium (Mg2+) [6], can reduce the risk of fracture by increasing BMD and BMC, and can reduce the risk of osteoporosis or fracture in elderly individuals [7]. Mg2+ deficiency is well known as a potential risk factor of osteoporosis [9], as well as a cause of impaired parathyroid hormone (PTH) secretion, which in turn dysregulates Ca2+
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