Abstract
Background The process of pain perception includes activation of peripheral nociceptors,transduction of nociceptive signals via the dorsal horn and activation of brain regions involved pain.But pain related molecular circuitry involving transduction of nociceptive signals is still unclear.Objective Review the application of novel optogenetics in pain research.Content Optogenetics can be used in characterizing pain related genes in model organism,studying the connection between peripheral nociceptors and spinal cord pain circuitry,and researching regulatory circuitry in pain involved brain regions.Trend Optogenetic techniques have advantage in selective activation of regional neuronal subpopulations which can provide a new tool to explore the complexity of pain pathway at the peripheral,spinal and supraspinal levels. Key words: Optogenetics; Pain; Dorsal horn; Amygdala; Prefrontal cortex ; Genetics
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.