Abstract

Background The process of pain perception includes activation of peripheral nociceptors,transduction of nociceptive signals via the dorsal horn and activation of brain regions involved pain.But pain related molecular circuitry involving transduction of nociceptive signals is still unclear.Objective Review the application of novel optogenetics in pain research.Content Optogenetics can be used in characterizing pain related genes in model organism,studying the connection between peripheral nociceptors and spinal cord pain circuitry,and researching regulatory circuitry in pain involved brain regions.Trend Optogenetic techniques have advantage in selective activation of regional neuronal subpopulations which can provide a new tool to explore the complexity of pain pathway at the peripheral,spinal and supraspinal levels. Key words: Optogenetics; Pain; Dorsal horn; Amygdala; Prefrontal cortex ; Genetics

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