Abstract
Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.
Highlights
Оптогенетические подходы к анализу роли дофаминергической нейромедиации в развитии зависимости от алкоголя: от корреляций к механизмам
Optogenetic approaches for the analysis of the role of dopaminergic neurotransmission in the development of alcohol dependence: from correlations to mechanisms
Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature
Summary
Оптогенетические подходы к анализу роли дофаминергической нейромедиации в развитии зависимости от алкоголя: от корреляций к механизмам. Несмотря на многолетнее изучение роли дофаминергических механизмов в процессе формирования алкогольной зависимости, полученные доказательства являются косвенными и корреляционными по своей сущности. В представленной работе мы использовали новейший оптогенетический подход для выявления роли дофаминергической нейромедиации в контроле мотивационного компонента потребления алкоголя.
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