Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

Laurent Tritschler,Mazen A Kheirbek,Yannick Le Dantec,Indira Mendez-David,Jean-Philippe Guilloux,Charlène Faye,Julie Doan,Thu Ha Pham,René Hen,Denis J David,Alain M Gardier

doi:10.1016/j.neures.2017.12.002

Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

Laurent Tritschler, Mazen A Kheirbek + Show 9 more

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https://doi.org/10.1016/j.neures.2017.12.002

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Journal: Neuroscience research	Publication Date: Dec 12, 2017
Citations: 10

Affiliation: Inserm, University of Paris-Saclay, University of Paris-Sud, Institut Polytechnique de Paris, Centre for Research in Epidemiology and Population Health, University of California, San Francisco, Columbia University

#Dopamine Release #NAcc Dopamine Release + Show 8 more

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Abstract

The dentate gyrus (DG) has distinct roles along its dorso-ventral axis. In the mouse, we recently demonstrated that dorsal DG (dDG) stimulation enhances exploratory behavior (Kheirbek et al., 2013). Dopamine (DA) release in the Nucleus Accumbens (NAcc), which belongs to the reward system, could be a key target of dDG mediating this motivation-related behavior. Here, an optogenetic stimulation of either ventral (vDG) or dDG granule cells was coupled with NAcc DA release monitoring using in vivo microdialysis. Only dDG stimulation enhanced NAcc DA release, indicating differential interconnections between dDG and vDG to the reward system.

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