Abstract
DNA sensing with engineered nanomaterials can bestow a new platform for single nucleotide identification and sequencing. Nevertheless, understanding the relevant nano-bio interfaces can provide a wealth of information on structures, energetics, and dynamics with a great potential in molecular nanotechnology. Herein, we explore the sensitivity of DNA units, the nucleotides, with a tiny probe, the diamond-like structures known as diamondoids. The probe diamondoid and the target nucleotides interact via hydrogen bonding, forming nano-bio complexes. The binding strengths for these complexes lie between the physisorption and chemisorption, allowing a suitable probe to sense the DNA nucleotides. Besides electronic properties, herein we investigate the optical properties of the nucleotides interacting with a functional diamondoid for the first time by assessing the absorption spectra and the charge dynamics within these complexes. The relative arrangements and bonding characteristics of the diamondoid with the n...
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