Opto-Acoustic Multimodal System to Delineate Adjacent Normal from Breast Biopsy Cancerous Tissue

Abstract

We propose a multimodal system combining the optical and ultrasound technique to characterize the bulk optical and acoustic breast biopsy tissue property. The bulk optical property consisting of optical reduced scattering coefficient <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$({\mu}_{\mathbf{s}})$</tex> . absorption coefficient (µa), and acoustic attenuation coefficient (a) are quantified to delineate between adjacent normal and cancerous breast biopsy tissue. It is observed that the cancerous tissue exhibits a higher µs” and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$a$</tex> compared to adjacent normal tissue, a basis for delineation between adjacent normal and cancerous tissue.