Options in predicting the effectiveness of tuberculosis therapy: focus on patients with chronic obstructive pulmonary disease

Abstract

Introduction. Tuberculosis (TB) and chronic obstructive pulmonary disease (COPD) belong to the category of co-morbid mutually aggravating diseases with an unfavor-able prognosis for working capacity and life. Objective of this study was to assess the possibility of predicting outcomes of TB treatment in patients with COPD. Ma-terials and methods: 514 patients were included in a simple comparative retrospective study. Patients were divided into 2 groups: group 1 — patients with new-ly diagnosed TB without COPD (310 patients), includ-ing 149 men (48.1%) and 161 women (51.9%) (χ2=0.89, p=0.345), age (Me (25.0; 75.0)) 40.41 (29.00; 49.50); group 2 — 204 TB+COPD patients, including 180 men (88.2%) and 24 women (11.8%) (χ2=41.15, p=0.000), age (Me (25.0;75, 0)) 48.25 (38.00; 57.00). The main factors influencing the severity of the disease and the outcome of treatment were identified, and the signs were graded. Using analy-sis of variance, the conditional probability of a favorable and unfavorable outcome of TB treatment for various combinations of signs was calculated. Results: When us-ing multivariate analysis of variance, the cumulative addi-tional effect of the trigger (years of smoking — shortness of breath — CAT test) on outcome was 29.8%, compared with a single effect of the studied signs. Conclusion. The outcome of TB treatment in comorbid patients is deter-mined not only by adequate TB chemotherapy, but also by the state of the bronchopulmonary system, which de-termines the main functions of life to prevent disability and mortality.