Abstract
ABSTRACTThe article studies the log-logistic class of dose–response bioassay models in the binomial set-up. The dose is identified by the potency adjusted mixing proportions of two similar compounds. Models for both absence and presence of interaction between the compounds have been considered. The aim is to investigate the D- and Ds-optimal mixture designs for the estimation of the full set of parameters or for the estimation of potency for a best guess of the parameter values. We also indicate how to find the optimal design to estimate the mixing proportions at which the probability of success attains a given value in the absence of the interaction effect.
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