Abstract
Mefenamic acid (MA) is a high-dose, anti-inflammatory, analgesic agent that is widely prescribed for pain related to menstrual disorders. It has some negative properties, such as a high hydrophobicity with a propensity to stick to surfaces, and possess great problems during granulation and tableting. Crystallization kinetics was investigated for mefenamic acid. Availability of data on the kinetics of crystal growth is very important for the development and operation of industrial crystallisation processes. The experiments for the measurement of crystal growth kinetics were carried out using the desupersaturation curve technique based on the measurement of the solution concentration versus time in a seeded isothermal batch experiment. To predict the optimum parameters (b, kb, g, kg) for the nucleation and growth kinetics from the desupersaturation curve obtained, the Population Balance Modelling was used and solved by the method of moments. The initial values for the optimisation problem were estimated by using the approach developed by Garside et al. (1982) [1].
Highlights
Mefenamic acid [N-(2,3-xyly) anthranilic acid] is a potent prostaglandin synthetase inhibitor that is widely used as a non-steroidal anti-inflammatory and analgesic-antipyretic drug
The simple Garside Method can be used for the rough estimations of the crystallisation growth kinetic parameters, the crystal growth rate constant and power of the mefenamic acid crystallisation process
The development and operation of industrial crystallisation processes can be made significantly easier if some data on the kinetics of crystal growth are available
Summary
Mefenamic acid [N-(2,3-xyly) anthranilic acid] is a potent prostaglandin synthetase inhibitor that is widely used as a non-steroidal anti-inflammatory and analgesic-antipyretic drug. Mefenamic acid is available in the form of tablets, capsules, and a pediatric suspension. Mefenamic acid is a problematic drug in granulation, tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surfaces. It has a prevalent usage in drug formulation. It is a poorly soluble drug in an aqueous media, sticking to any type of surface, and is not handled in the granulation and tableting processes. Enhance dissolution rates, and develop a stable and reproducible dosage form, investigation of the physicochemical properties of mefenamic acid is necessary
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