Abstract
Copyright © 2016 by Turkiye Klinikleri ABSTRACT Objective: In Metronomic Chemotherapy (MC) performance of specific surrogate markers plays an important role to obtain the effective treatment. It is very difficult to detect the initial threshold value of surrogate markers to get an idea about optimum dose level of MC for long-term effective treatment. The long-term effective treatment can be obtained through controlling the surrogate markers on continues measured value into a specific range. The long-term effective treatment is defined as long-term recurrence-free survival. During the treatment initiation, many surrogate markers value changes rapidly and those values are time-dependent measurements. The specification of surrogate markers threshold value can only be obtained through the application of ROC curve (AUC), Sensitivity, and Specificity analysis. Material and Methods: The application of ROC curve to detect the timedependent continuous measurement becomes complicated. In this paper, a straightforward Survival Analysis estimator through MCMC iteration for each possible time point measurement is adopted to detect the possible threshold value of surrogate markers. Results: The surrogate markers levels on angiogenesis in Head and Neck Cancer (HNC) patients are considered. Conclusion: The threshold value of the surrogate markers is detected through the formation of ROC curve.
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