Abstract
(JAMA. 2018;319(21):2173–2174) While preterm newborns were once routinely exposed to unrestricted oxygen therapy, in the 1950s it was suggested that there may be an association between this practice and development of retinopathy of prematurity. Since then, 2 randomized clinical trials have supported this association [Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP) and Benefits of Oxygen Saturation Targeting (BOOST)] and also revealed that higher SpO2 ranges significantly increased the risk of severe pulmonary morbidity.
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