Abstract
Optimizing Oral Controlled Release Drug Delivery Systems Using Experimental Designs
Highlights
The use of optimization techniques employing design of experiments (DoE), permeated the field of pharmaceutical product/process development around four decades ago
The number of optimization studies would be much higher in the drug industry, where DoE methods are applied much more frequently
Many more endeavors have to be undertaken to highlight the enormous benefits of these techniques before this can happen as a global trend
Summary
The use of optimization techniques employing design of experiments (DoE), permeated the field of pharmaceutical product/process development around four decades ago. The controlled release drug delivery systems for oral use are solid dosage forms, based upon the mechanism of diffusion, dissolution, or a blend of both to control the release rate of drug. These include reservoir devices wherein a polymeric membrane surrounds a drug core and matrix devices wherein the dissolved or dispersed drug is distributed uniformly in an inert polymeric matrix. Spray-dried Rice Starch, Croscarmellose sodium, magnesium Stearate, compression force
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