Abstract
A research on optimizing conditions to cholesterol adsorbed have been performed. Optimization was performed by varying: contact time, adsorbent weight and temperature of the system's. A full factorial experimental design was used in this study. Characterization performed on the synthesized chitosan and carboxymethyl chitosan including FTIR, water content, ash content, solubility, porosity, and swelling effect. The results showed that carboxymethyl chitosan able to adsorb cholesterol under conditions optimal adsorbent with cholesterol ratio (1:200) with a contact time of 90 minutes at temperature of 40 °C. Meanwhile, at a temperature of 55 °C carboxymethyl chitosan capable of adsorb cholesterol under conditions optimal adsorbent with cholesterol ratio (1:300) with a contact time of 30 minutes. Chitosan and carboxymethyl chitosan synthesized has a water content of 7.4 and 10.2%, ash content of 0.14 and 2.29%, solubility in distilled water at 1.10-5and 1.98.10-3%, solubility in acetic acid 0.02 and 0.04%, porosity at 88.3% and 88.8%, and swelling at 163.13 and 182.98%.
Highlights
Struktur kolesterol mengandung 27 karbon, banyak ditemukan sebagai komponen dalam membran sel
The results showed that carboxymethyl chitosan able to adsorb cholesterol under conditions optimal adsorbent with cholesterol ratio (1:200) with a contact time of 90 minutes at temperature of 40 °C
Solid-state characterization of chitosans derived from lobster chitin
Summary
ABSTRAK Telah dilakukan optimasi kondisi adsorpsi kolesterol menggunakan karboksimetil kitosan. Kitosan dan karboksimetil kitosan hasil sintesis dikarakterisasi menggunakan FTIR, dan ditentukan kadar air, kadar abu, kelarutan, porositas serta efek swelling. Hasil penelitian menunjukkan bahwa pada suhu sistem 40 °C karboksimetil kitosan mampu mengadsorpsi kolesterol secara optimal pada kondisi perbandingan adsorben dengan kolesterol (1:200) selama waktu kontak 90 menit. Sedangkan pada suhu sistem 55 °C karboksimetil kitosan mampu mengadsorpsi kolesterol secara optimal pada kondisi perbandingan adsorben dengan kolesterol (1:300) selama waktu kontak 30 menit. Kitosan dan karboksimetil kitosan hasil sintesis memiliki kadar air sebesar 7,4 dan 10,2%, kadar abu sebesar 0,14 dan 2,29%, kelarutan dalam aquades sebesar 1,10-5 dan 1,98.10-3%, kelarutan dalam asam asetat sebesar 0,02 dan 0,04%, porositas sebesar 88,3 dan 88,8% serta swelling sebesar 163,13 dan 182,98%.
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