Optimizing antioxidant properties of salam (Syzygium polyanthum) leaf extract through nanoencapsulation technology

Abstract

Nanoencapsulation preparation was carried out to optimize the antioxidant properties of salam leaf extract (Syzygium polyanthum). The ionic gelation method was used in the process of making nanoencapsulation with chitosan and Sodium Trypolypospat (STPP) as a coating material. The parameters observed included the antioxidant activity of salam leaf extract and the characteristics of the nanoencapsulation of salam leaf extract. NSLE characterization was measured, such as particle size, zeta potential (using Particle Size Analyzer), and nanoparticle morphology (using Transmission Electron Microscopy). Descriptive analysis was used to discuss the results obtained which are equipped with tables and figures. The results showed that the optimum formulation of NSLE was the ratio of extract nanoencapsulation: chitosan: STPP was 1: 4: 1/90. The antioxidant activity of the salam leaf extract was 68.55%, then the measured NSLE particle size was 478.3 nm with a Polydispersity Index (PI) of 0.52 and a measured zeta potential value of + 42.3 mV. NSLE particle morphology looks round with a rough surface. Characterization of NSLE has the potential to protect bioactive compounds so that they can optimize the performance of antioxidant activity.