Abstract
In this study the phenolic compounds piceid, resveratrol and emodin were extracted from P. cuspidatum roots using ultrasound-assisted extraction. Multiple response surface methodology was used to optimize the extraction conditions of these phenolic compounds. A three-factor and three-level Box-Behnken experimental design was employed to evaluate the effects of the operation parameters, including extraction temperature (30–70 °C), ethanol concentration (40%–80%), and ultrasonic power (90–150 W), on the extraction yields of piceid, resveratrol, and emodin. The statistical models built from multiple response surface methodology were developed for the estimation of the extraction yields of multi-phenolic components. Based on the model, the extraction yields of piceid, resveratrol, and emodin can be improved by controlling the extraction parameters. Under the optimum conditions, the extraction yields of piceid, resveratrol and emodin were 10.77 mg/g, 3.82 mg/g and 11.72 mg/g, respectively.
Highlights
IntroductionCalled Huzhang, belongs to the Polygonaceae family and is a perennial herb widely distributed in Asia and North America
Polygonum cuspidatum, called Huzhang, belongs to the Polygonaceae family and is a perennial herb widely distributed in Asia and North America
Response surface methodology (RSM) combined with a three-level, three-factor Box-Behnken design was employed in this study
Summary
Called Huzhang, belongs to the Polygonaceae family and is a perennial herb widely distributed in Asia and North America. The roots of P. cuspidatum are used as a traditional Chinese medicinal herb for the treatment of arthralgia, chronic bronchitis, jaundice, amenorrhea, hypertension, and hypercholesterolemia [1]. The known phenolic compounds found in the roots of P. cuspidatum mostly associated with these properties are resveratrol, piceid, and emodin [2,3]. Phenolic compounds can readily form resonance-stabilized phenoxy radicals that possess good antioxidant activities [4,5]. Resveratrol and piceid have been shown to possess various biological activities such as antioxidant, anti-inflammatory, anti-cancer, anti-aging and cardioprotective properties [6,7,8]. Emodin has been shown to possess anti-inflammatory, antibacterial, and antineoplastic activities [9,10,11,12]
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