Abstract
The study was conducted to establish a model system for in vitro biomass production, biochemical characterization and evaluation of chemo-preventive properties against mutagenicity in transgenic rats of a selected germplasm line (HQ 111) of Chinese medicinal plant species Scutellaria baicalensis Georgi (Huang-qin). Biomass production was assessed in different in vitro growing systems as a means of large-scale, biotic or abiotic contaminant-free production. Result revealed that the plantlets grown in a temporary immersion bioreactor showed the highest accumulation of biomass, while plantlets grown on solid medium in a CO2 enriched environment had the highest concentrations of bioactive metabolites. Supplementation of feed with S. baicalensis decreased the mutagenicity of aflatoxin-B1 in the liver of lacI transgenic rats providing evidence of efficacy of the optimized germplasm as an anticancer agent. The system described in the current study represents a novel approach to medicinal plant research highlighting the optimized production conditions for biomass production and phytochemical content in plant tissues of a selected superior plant germplasm and the evaluation of whole plant preparations in an animal model system.
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