Optimized single pulse stimulation strategy for retinal implants

Abstract

Retinal implants offer prospects of vision restoration for some blind patients by eliciting visual percepts of spots of light called ‘phosphenes’. Recently, a mathematical model has been developed that predicts patients' perception of phosphene brightness for current-driven electrical stimulation of the retina. This model is explored for different stimulation parameters on a single electrode, including safety and hardware limitations, to produce phosphenes of specified brightness. We describe a procedure to derive stimulation parameters to account for such constraints, and describe methods to construct optimal stimuli in terms of producing maximal perceived brightness and efficient generation of phosphenes of a given brightness by employing minimal energy. In both cases, it is found that the resulting optimized stimulation waveforms consist of a long stimulation period, and interphase delays between initial and charge-balancing phases.