Abstract
Formulation and Evaluation of Gastroretentive Floating Tablets of Domperidone MaleateD. Saritha, D. Sathish, Y. Madhusudan Rao
Highlights
Carvedilol (CVD) is clinically prescribed in the management of hypertension, myocardial infarction and congestive heart failure (Wen et al, 2010)
The present study aimed to prolong its gastric residence time that entailed a development of an optimized gastro retentive floating tablets (GRFTs) using 32full factorial design
Quality attributes of the prepared CVD-GRFTs CVD-GRFTs were developed using release controlling polymers such as HPMC and CRP, and gas generating agent like NaHCO3and citric acid
Summary
Carvedilol (CVD) is clinically prescribed in the management of hypertension, myocardial infarction and congestive heart failure (Wen et al, 2010). It exhibits low bioavailability (about 25%) after oral administration due to extensive first-pass metabolism in liver. It has a short plasma half-life of about 6 hours with an elimination half-life of 2 hours (Neugebauer et al, 1990; Tanwar et al, 2007; Ubaidulla et al, 2007). It’s extremely lower solubility at alkaline pH levels may affect its availability at the absorptive site (Chakraborty et al, 2009). The development of CVD in a gastro retentive floating dosage form making it excellent candidate for improving solubility, enhancing absorption and controlling its release
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