Abstract
.The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence tomography (OCT) signals can provide additional information and can increase the potential for OCT applications. We present an optimized depth-resolved estimation (ODRE) method that derives a precise mapping between the measured OCT signal and the OAC. In contrast to previous depth-resolved estimation (DRE) methods, the optimized method can estimate the OAC in any depth range and ignore whether the light is completely attenuated. Numerical simulations and phantom experiments are used to verify its validity, and this method is applied to detect cerebral damage. In combination with OCT angiography, real-time observation of the change of blood perfusion and the degree of cerebral damage in mice with focal cerebral ischemia provides important information to help us understand the temporal relationship between brain damage and ischemia.
Highlights
Optical coherence tomography (OCT) is a promising noninvasive imaging modality in vivo for label-free three-dimensional tissue imaging in vivo.[1]
The optical attenuation coefficient (OAC) of the simulated data were estimated by the method of depth-resolved estimation (DRE) and optimized depth-resolved estimation (ODRE), respectively
For the DRE method, the entire imaging depth was used for OAC estimation
Summary
Optical coherence tomography (OCT) is a promising noninvasive imaging modality in vivo for label-free three-dimensional tissue imaging in vivo.[1] In recent years, methods for calculating attenuation coefficients from OCT signals to identify various tissue types and obtain their pathological status information have begun to attract the attention of scholars. OAC increases during cerebral ischemia.[3] Observations of ischemia tissue by transmission electron microscopy suggest that the increase in OAC is due to deformation or enlargement of mitochondria and dendrites expansion.[4] Through quantitative measurement of OAC, cerebral tissue damaged by ischemia can be effectively labeled and evaluated This method provides additional information and increases the potential of OCT in exploring cerebral infarction. The changes in blood perfusion and the degree of brain injury in mice with focal cerebral ischemia are observed in real time, and the relationship between the two is analyzed
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