Abstract
Advantageous qualities of non-porous silica-based particles for reversed-phase protein separations include fast mass transfer kinetics, efficient solute resolution and great mechanical stability. Such qualities are shown to be enhanced by their employment in an optimized LC instrument for extremely efficient and rapid separations of proteins. In order to demonstrate optimization strategies, the advantages/disadvantages of varying gradient time, flow-rate, temperature, packing hydrophobicity, starting conditions, and sample pretreatment are shown.
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