OPTIMIZATION OF VITAMIN D LEVEL WITH AN ASSESSMENT OF THE EFFECT ON THE MORPHOFUNCTIONAL STATE OF THE MYOCARDIUM IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED EJECTION FRACTION

Abstract

Objective: to evaluate the effectiveness of intake of vitamin D-containing drugs at different dose modes with an assessment of 25-hydroxy-cholecalciferol (25(ОН)D) level and echocardiography parameters in patients with chronic heart failure with preserved ejection fraction (CHF-PEF). Material and methods. 82 patients with CHF-PEF and D-hypovitaminosis were divided into 4 groups: group I (n = 26) - received Cholecalciferol 2000 IU/day, group II (n = 16) - 1000 IU/day, group III (n = 23) - a vitamin D-containing food additive, the comparison group (n = 17) - underwent only complex pathogenetic CHF therapy. Results. The 25(OH)D level in group I reached the optimal level in 84.6 % persons, in group II - in 56.2 % (p = 0.04), in group III - in 69.6 %, in the comparison group in 29.4 % (p = 0.0006). The level of 25(OH)D was negatively associated with the thoracic aorta diameter and end-diastolic volume of the left ventricle (EDV-LV). Conclusion. Optimization of 25(OH)D has a positive effect on the thoracic aorta diameter, anterior-posterior size of the left atrium and EDV-LV.