Optimization of ultrasound-assisted extraction of bioactive compounds from Gomphrena celosioides Mart. using response surface methodology

N T H Yen,L P T Quoc

doi:10.4314/bcse.v34i2.3

Abstract

In this study, ultrasound-assisted extraction (UAE) was used to extract bioactive compounds from Gomphrena celosioides Mart. Central composite face design (CCF) was used to optimize the influences of extraction factors on total phenolics content (TPC), total flavonoids content (TFC), and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging capacity (DPPH-RSC). The results obtained showed that all factors (solvent to solid ratio, extraction time and extraction temperature) strongly affected TPC, TFC, and DPPH-RSC. The optimal extraction conditions for TPC (3.123 mg GAE/g DW), TFC (1.736 mg QE/g DW), and DPPH-RSC (64.118%) were solvent to solid ratio of 27.3/1 (mL/g), extraction time of 40.2 min, and extraction temperature of 69 oC. In addition, under the optimal conditions, the results pointed out that the experimental values agreed with those predicted. Hence, this model has successfully optimized the extraction conditions for TPC, TFC and DPPH-RSC of Gomphrena celosioides extract.  KEY WORDS: Antioxidant activity, CCF, Flavonoids, Model, Phenolic compounds, Regression equation  Bull. Chem. Soc. Ethiop. 2020, 34(2), 237-248 DOI: https://dx.doi.org/10.4314/bcse.v34i2.3

Highlights

The herbal plants were widely used in the pharmaceutical industry and the use of herbal medicines has provided a good opportunity for Vietnam to develop therapeutic compounds from an ancient system of therapy
According to the study of Pendse [1], natural product origin can produce over 50% of all modern drugs and the phytoconstituents of the herbal plant have an indispensable role in the pharmaceutical and medical industry
One of herbal plant is Gomphrena celosioides Mart. (Common name: Bachelor's button or Prostrate globe-amaranth) that belongs to family Amaranthaceae, and originates from America, especially South America (Brazil, Paraguay, Uruguay, and Argentina)

Summary

Introduction

The herbal plants were widely used in the pharmaceutical industry and the use of herbal medicines has provided a good opportunity for Vietnam to develop therapeutic compounds from an ancient system of therapy. Plants contain a large number of bioactive constituents with diverse pharmacological properties and medicinal values. They can manufacture many novel drugs with the high therapeutic value. (Common name: Bachelor's button or Prostrate globe-amaranth) that belongs to family Amaranthaceae, and originates from America, especially South America (Brazil, Paraguay, Uruguay, and Argentina). This plant has spread throughout the tropical regions in the world [2] and it can be harvested all year round in Vietnam. All parts of this plant are useful, and they can cure many diseases such as antimicrobial, anticancer, antimalarial, analgesic, diarrhea, gastric disturbances, piles, and dermatitis [3]

Methods

Results

Conclusion