Abstract
The leaves of Plectranthus amboinicus (Lour.) Spreng. (Lamiaceae) is a perennial plant that contained flavonoids compounds with have antidiabetic properties. The aim of the work was to select the best solvent for extraction of the flavonoid compounds from torbangun leaves. A statistical simplex-centroid mixture design for the water, ethanol, and hexane solvents has been used to the extraction of extract yield, flavonoids content, and inhibitory α-glucosidase activity of torbangun leaves. The ethanol-water extracts showed the highest extract yield with value of 15.92%. The ethanol-hexane extracts presented the highest total flavonoids content, 96.30 mg QE/g, followed by hexane extract (82.91 mg QE/g). The ethanol extract recorded higher inhibitory of α-glucosidase activity, with value of 25.53%, followed by hexane extract (25.21%), and ethanol-water extract (23.02%). The weak correlation between the α-glucosidase inhibition and total flavonoids content showed that flavonoids contribute non-significantly to the α-glucosidase activity.
Highlights
Plectranthus amboinicus (Lour.) Spreng., familyLamiaceae and commonly known as torbangun name in Indonesia, is a perennial plant that distributed in Asia, Australia, and Tropical Africa (Lukhoba, Simmonds, & Paton, 2006)
Polyphenolics, such as flavonoids compounds, are one of the secondary metabolites which contained in the torbangun leaves (El-hawary, El-sofany, AbdelMonem, Ashour, & Sleem, 2012)
This study used a simplexcentroid model with water, ethanol, and hexane as solvents to optimize the flavonoids extraction in torbangun leaves
Summary
Lamiaceae and commonly known as torbangun name in Indonesia, is a perennial plant that distributed in Asia, Australia, and Tropical Africa (Lukhoba, Simmonds, & Paton, 2006). The torbangun leaves have been used for antirheumatic (Chang, Cheng, Hung, Chung, & Wu, 2010), anti-diarrhea (Shubha & Bhatt, 2015), antibacterial (Aguiar et al, 2015; Vijayakumar, Vinoj, Malaikozhundan, Shanthi, & Vaseeharan, 2015), anti-fungi (Murthy, Ramalakshmi, & Srinivas, 2009), anti-streptococcal (Zhang, Wijesundara, Abbey, & Rupasinghe, 2017), anti-inflammatory and antitumor (Gurgel et al, 2009), and anti-diabetic (Govindaraju & Arulselvi, 2018) activities Polyphenolics, such as flavonoids compounds, are one of the secondary metabolites which contained in the torbangun leaves (El-hawary, El-sofany, AbdelMonem, Ashour, & Sleem, 2012). We have tried to optimize the solvent type and their mixtures on the extract yield, flavonoids contents, and activity of α -glucosidase inhibition from torbangun leaves. This study used a simplexcentroid model with water, ethanol, and hexane as solvents to optimize the flavonoids extraction in torbangun leaves.
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