Abstract
In this study, a method to improve the detection accuracy of a “weak measurement” system of optical rotation was proposed by determining the optimal total phase difference of the system. Analysis of the characteristics of weak measurement regime of the system under different total phase differences provided the total phase difference corresponding to the regime with the smallest ratio of system noise level to sensitivity (that is, the highest system resolution). In this regime, an optical rotation resolution of 5.522 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> ° was obtained, which is nearly an order of magnitude higher than the original system.
Highlights
Improvement in optical detection technology has played an important role for discovery research in biological sciences
We focused on the weak optical rotation measurement system, and determined the regime of the minimum value of the ratio of the system's noise level and sensitivity through numerical simulation calculations, thereby significantly improving the detection accuracy of the system
The sensitivity and noise level of a weak measurement system can be represented by the central wavelength offset and the standard deviation of the central wavelength in a bimodal spectrum, respectively that are caused by a change of 1 unit of the quantity to be measured in the system
Summary
Improvement in optical detection technology has played an important role for discovery research in biological sciences This is mainly attributed to its non-destructive, non-labeling, and highly sensitive nature. We focused on the weak optical rotation measurement system, and determined the regime of the minimum value of the ratio of the system's noise level and sensitivity through numerical simulation calculations, thereby significantly improving the detection accuracy of the system. A solution of L-proline was used to perform a sample detection test at the calculated regime of the optimal total phase difference of the weak measurement system and an optical rotation detection resolution of 5.522×10-6°, which is nearly one order of magnitude higher than the previous system [11], was obtained
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