Abstract
Soft tissue sarcomas (STS) constitute a heterogeneous group of rare solid tumors associated with significant morbidity and mortality. The evaluation and treatment of STS require a multidisciplinary team with extensive experience in the management of these types of tumors. National and international clinical practice guidelines for STS do not always provide answers to a great many situations that specialists have to contend with in their everyday practice. This consensus provides a series of specific recommendations based on available scientific evidence and the experience of a group of experts to assist in decision-making by all the specialists involved in the management of STS.
Highlights
Localized high-risk (Table 1) Soft tissue sarcomas (STS) are defined as those that meet the following criteria: G3, >5 cm, and deep-seated [11]. e panel of experts accepted this definition and, in turn, determined that since not all histological subtypes of G3 STS exhibit uniform behavior, cases in which G2 is established by needle biopsy (Tru-Cut) with necrosis of at least 50% seen on MRI should be considered high risk
E results of the study by Tanaka et al support the use of preoperative chemotherapy followed by postoperative chemotherapy consisting of three cycles of doxorubicin 60 mg/m2 and ifosfamide 10 g/m2 for localized high-risk extremity or trunk wall STS [13]
The noninferiority of three cycles of a full-dose conventional chemotherapy in comparison with five cycles and the association between response to therapy and better rates of overall survival (OS), when Choi criteria are used for the evaluation, have been pinpointed in a randomized trial [11]
Summary
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