Abstract
Celecoxib was labelled effectively with 99mTc. The labeling yield was found to be influenced by the amount of celecoxib, the amount of stannous chloride dihydrate, the reaction time, the temperature and the pH of the reaction mixture. The importance of stannous chloride dihydrate arises from its function as a reducing agent for pertechnetate to form complex celecoxib. The suitable amount required to produce high labeling yield of 99mTc-celecoxib was 500 μg SnCl2·2H2O. The pH of the reaction medium was found to play a significant role in this labeling process. The labeling reaction was performed at a neutral medium (pH 7). The labeling reaction proceeds well at room temperature (25 ± 1 °C) and the complex decomposes by heat. The labeled celecoxib (99mTc-celecoxib) showed a good localization in inflamed foci and a good imaging must be taken 4 h post injection.
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