Abstract
Allergic pathology is one of the most pressing issues in contemporary medicine. The most important task during the treatment of allergic diseases is the determination of cause-significant allergens. Nowadays, the identification of specific IgE in the blood serum is widely used in Ukraine for the diagnostics of food and respiratory allergies. The majority of the laboratories offer the identification of specific IgE in the form of panels, the composition of which not exactly corresponds to our regional peculiarities. This article presents the results of the analysis of 790 medical histories of children aged 3–17 years with allergic pathology. Sensitization to allergens has been identified by determining the specific IgE in the blood serum and by skin prick testing. As a result, the following relevant food allergens were detected: fish, beans, strawberry, wild strawberry, apricot, peach, raspberry, cherry, sweet cherry, plum, apple, pear, citrus fruits, chicken protein, cow’s milk protein. Representative pollen allergens of Kharkiv region are: ragweed, sagebrush, sumpweed, dandelion, buckwheat, sorrel, poplar, acacia, maple, alder, oak. To optimize laboratory diagnostics in the Kharkiv region when preparing test panels, it is recommended to separately identify food and pollen allergens based on their relevance. The composition of the panels of pollen allergens should be reviewed, taking into account the data of the regional aeropalynologic researches.
Highlights
Allergens that play a part in the development of respiratory allergic diseases have substantial regional distinctions due to the diversity of climate, flora, periods of plant pollination, properties of pollen
Determining the relevant food and pollen allergens in the Kharkiv region for the optimization of laboratory diagnosis of allergic diseases among children
We have combined all the allergens in groups according to the generality of the antigenic structure: cow protein, chicken protein, fish, gluten cereals, gluten-free cereals, Rosaceae, citrus fruits, Solanaceous, carrot, legumes, pork, Cucurbitaceae, as well as cabbage, beetroot, onions, banana, currants, black tea, grapes (Fig. 1)
Summary
Food allergy is the first temporal development form of sensitization and has significant influence on the formation and subsequent development of all allergic di (66) 2015 seases of children. Different countries have their own regional food allergens, which depend on the climate and geographical location of the country and characteristics of the population’s diet. Allergens that play a part in the development of respiratory allergic diseases (bronchial asthma, allergic rhinitis) have substantial regional distinctions due to the diversity of climate, flora, periods of plant pollination, properties of pollen (in particular, the change of its allergenic qualities depending on the ecological state of the environment). Significant differences in the spectrum of Адреси для листування з авторами: Клименко Вікторія Анатоліївна
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