Optimization of Synthetic Condition for 2’hydroxy Chalcone by using Mixture Design

Abstract

Chalcone derivatives are crucial compounds in pharmaceutical industry for synthesis of different heterocyclic compounds. Chalcone derivatives have variety of biological activities. For the synthesis of chalcone derivatives, Clainsen-Schmidt condensation is widely used method in which strong base abstract proton from alpha position and generates carboanion in presence of alcoholic solvents. Generated carboanion reacts with benzldehyde under condensation and generated chalcones. Reproducibility of this reaction is very poor. In presence study mixture design used to optimize synthetic condition of 2’hydroxy chalcone. Amount of solvent, amount of catalyst, temperature and stirring time was taken as independent variables and % yield taken as dependent variable. After the applying mixture design and ANOVA predicted % yield was 96.55% and experimental value was 95.55%. With the help of mixture design reaction conditions were successfully optimized.