Abstract
Prosopis farcta, a plant belongs to the mimosoideae, is characterized by a very wide spectrum of various bioactive and medical constituents. Vitexin, the marker flavonoid found in Prosopis, has potent and broad antitumour efficacy in preclinical models. Many studies had been done for the isolation of flavonoids (vitexin) by completely different chromatographically methodology. During this study, vitexin was isolated from Prosopis farcta by 6 different extraction methods in which parameters as the type, concentration and pH of the extracting solvents considered. Among different solvent systems used, methanol-water (40%, containing acetic acid 0.5%) was found to be the best solvent generating the highest yield (0.554 mg·g-1 DW) from Prosopis leaves. The present work suggests an efficient method for estimation the greatest content of vitexin analyzed by HPLC technique and introduces Prosopis farcta as a suitable source of this flavonoid with several pharmacological properties.
Highlights
The genus Prosopis (Leguminosae, subfamily Mimosoideae) includes about 50 species
The present work suggests an efficient method for estimation the greatest content of vitexin analyzed by High performance liquid chromatography (HPLC) technique and introduces Prosopis farcta as a suitable source of this flavonoid with several pharmacological properties
Vitexin peaks were identified in the extracts by comparing the retention time with that obtained from the standard solution (Figure 2), by spiking the standard solution into the sample solution and by a comparison of its UV spectra with that of the standard (Figure 3)
Summary
The genus Prosopis (Leguminosae, subfamily Mimosoideae) includes about 50 species. Species of Prosopis are often spiny trees or shrubs predominantly well adapted to hot, arid climates. These plants have been commonly distributed in northern Africa, Southwestern Asia, West to the Middle East, and in the USA. Prosopis farcta is a native of Asia, distributed from India to Iran [1]. P. farcta has been used as a traditional medicine for treatment of some diseases and disorders.
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