Optimization of Simulated Moving Bed Processes

Abstract

In this contribution, the optimization of periodic chromatographic simulated moving bed SMB processes is discussed. The rigorous optimization is based on a nonlinear pde model which incorporates rigorous models of the chromatographic columns and the discrete shifts of the inlet and outlet ports. The potential of the optimization is demonstrated for a separation problem with nonlinear isotherm of the Langmuir type for an SMB process and the ModiCon process. Here, an efficient numerical approach based on multiple shooting is employed. An overview of established optimization approaches for SMB processes is given.