Abstract
A new rapid, simple and reproducible UV spectrophotometric method was developed and validated for the estimation of Naproxen Sodium (NpSd) in bulk and pharmaceutical formulation. The quantification of NpSd was done at 230 nm in methanol and in buffer of pH 6.8 and 9. Beer’s law was obeyed in the concentration range of 4 - 36 (r2 = 0.999) in methanol and 5 - 25 μgmL﹣1 in buffer of pH 6.8 and 9 (r2 = 0.988 and 0.997) respectively. The apparent molar absorptivity values were also calculated in all mediums. All parameters according to ICH guideline were tested and validated. The detection and quantitation limits were found to be 0.054, 0.083, 0.073 and 0.181, 0.251, 0.211 μgmL﹣1 respectively. These methods were applied directly to the analysis of the pharmaceutical tablet preparations (Anex? tablet 250 mg). The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation 3%), while being simple, cheap and less time consuming and hence can be suitably applied for the estimation of NpSd in dosage forms and dissolution studies.
Highlights
Naproxen (NpSd), a non-steroidal anti-inflammatory drug, is chemically [(+)-2-(6-methoxy-2-naphthyl) propionic acid with anti-inflammatory, analgesic and antipyretic properties, commonly used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout (Figure 1)
Anti-inflammatory effects of Naproxen Sodium (NpSd) are generally thought to be related to its inhibition of cyclooxygenase and formulated in tablets or suppositories, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout [1]
Naproxen sodium (NpSd) yields a characteristic curve in all mediums when scanned in the ultraviolet wavelength range
Summary
Naproxen (NpSd), a non-steroidal anti-inflammatory drug, is chemically [(+)-2-(6-methoxy-2-naphthyl) propionic acid with anti-inflammatory, analgesic and antipyretic properties, commonly used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout (Figure 1). It is often preferred to acetylsalicylic acid (aspirin) because of its better absorption following oral administration and poses fewer adverse effects It works by inhibition of both the COX-1 and COX-2 enzymes with consequent decrease in prostaglandin concentrations in various fluids and tissues. Anti-inflammatory effects of NpSd are generally thought to be related to its inhibition of cyclooxygenase and formulated in tablets or suppositories, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout [1]. Present paper was undertaken with the aim to develop an accurate, simple and reliable UV method for estimation of naproxen API and applied to OPEN ACCESS
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