Abstract
Purpose: To develop a nanosuspension drug delivery system to enhance the dissolution rate of Silybum marianum seeds extract.
 Methods: Central composite design was used to study the effect of the input variables (stabilizer to plant extract ratio, antisolvent to solvent ratio, stirring time) on the dependent variables (mean particle size, polydispersity index (PDI) and zeta potential). The optimized formulation was characterized by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), Fourier Transformed Infrared Microscopy (FT-IR) and in vitro dissolution testing.
 Results: The optimized nanosuspension with mean particle size of 137 nm, PDI of 0.327 and zeta potential of -37 mV was obtained. SEM studies revealed irregular shaped particles. AFM studies showed nanosized particles with good surface characteristics. The optimized formulation showed faster dissolution rate than coarse suspension.
 Conclusion: Results suggested that nanosuspension has remarkable potential for enhancement of the dissolution properties of poorly soluble S. marianum seed extract.
 Keywords: Silybum marianum; Nanosuspension; Optimization; Dissolution rate
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