Abstract
Objective: to comparatively evaluate the analgesic activity and hemostatic effects of two nonsteroidal anti-inflammatory drugs (NSAID) that are most commonly used for postoperative analgesia — ketorolac and ketoprofen in patients operated on for diffuse nodular nontoxic goiter. Subjects and methods. At surgical treatment stages, the authors examined the degree of the pain syndrome by the visual analog scale and hemostatic parameters in 90 patients divided into three groups according to the postoperative analgesia mode (ketorol, ketonal, and promedol). Results. Postoperative analgesia in nontoxic goiter patients with ketorol and ketonal has been ascertained to be highly competitive with that with promedol and to give no rise to clinically significant complications inherent in NSAID. Ketorol provides a rapider, prolonged and effective postoperative analgesia than does ketonal. Ketorol affects the hemostatic system to a lesser extent than does ketonal. Conclusion. Ketorol analgesia may be considered to be the method of choice of postoperative analgesia in patients with nontoxic goiter. Key words: ketorol, ketonal, hemostasis, analgesia.
Highlights
Objective: to comparatively evaluate the analgesic activity and hemostatic effects of two nonsteroidal anti inflammatory drugs (NSAID) that are most commonly used for postoperative analgesia — ketorolac and ketoprofen in patients operated on for diffuse nodular nontoxic goiter
The authors examined the degree of the pain syndrome by the visual analog scale and hemostatic parameters in 90 patients divided into three groups accord ing to the postoperative analgesia mode
Ketorol affects the hemostatic system to a lesser extent than does ketonal
Summary
Сравнительная оценка анальгетической активности и степени влияния на систему гемостаза двух наиболее часто используемых для послеоперационного обезболивания НПВП — кеторолака и кетопрофена у боль ных, оперированных по поводу диффузно узлового нетоксического зоба. Postoperative analgesia in nontoxic goi ter patients with ketorol and ketonal has been ascertained to be highly competitive with that with promedol and to give no rise to clinically significant complications inherent in NSAID. Ketorol analgesia may be considered to be the method of choice of postoperative analgesia in patients with nontoxic goi ter. Rusy et al [3], обнару жили, что кеторолак более эффективен при лечении бо ли после тонзиллэктомии у детей по сравнению с ацетаминофеном. Учиты вая кратковременность использования НПВП с целью послеоперационного обезболивания, наиболее опасными осложнениями при их применении являются расстрой ства системы гемостаза.
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