Abstract

Efficient, original synthesis of poly(glycerol sebacate) (PGS) via polycondensation of glycerine and sebacic acid was achieved. The process was successfully optimized by using the Box–Behnken design. PGS was obtained with a high conversion of the carboxylic group (89%) and a very high degree of esterification (∼82%), containing no catalysts residues. A method was developed for purification of prepolymer PGS. Because biocompatible substrates are used, this method for obtaining the polymer can be used in medical and pharmaceutical applications.

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