Optimization of pineapple juice amount used as a negative oral contrast agent in magnetic resonance cholangiopancreatography

Matteo Renzulli,Rita Golfieri,Maurizio Biselli,Stefano Brocchi,Nicolò Brandi,Irene Pettinari,Daniele Caretti,Alessandro Sergenti

doi:10.1038/s41598-021-04609-6

Matteo Renzulli, Rita Golfieri + Show 6 more

Open Access

https://doi.org/10.1038/s41598-021-04609-6

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Journal: Scientific Reports	Publication Date: Jan 11, 2022
Citations: 3	License type: open-access

Affiliation: Azienda USL di Bologna, University of Bologna

Abstract

To evaluate the potential variability of Manganese (Mn2+) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn2+ concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress the gastroduodenal (GD) liquid signal. The Mn2+ concentration in PJ produced in different years was defined using Atomic Absorption Spectrometry. The optimal Mn2+ concentration and the amount of PJ, were estimated in an in-vitro analysis, and were then prospectively tested in a population of patients who underwent MRCP. The results were compared with those achieved with the previous standard amount of PJ used in a similar population. The concentrations of Mn2+ in commercial PJ produced in different years did not differ. A total amount of 150 ml (one glass) of PJ having a high Mn2+ content (2.37 mg/dl) was sufficient for the suppression of the GD liquid signal, despite the additional dilution caused by GD liquids since it led to a final concentration of Mn2+ of 0.5–1.00 mg/dl. The optimized single-dose oral administration of 150 ml (approximately one glass) of PJ having a high Mn2+ concentration prior to MRCP was adequate to guarantee the correct amount of Mn2+ to suppress the GD signal.

Highlights

To evaluate the potential variability of Manganese (Mn2+) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn2+ concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress the gastroduodenal (GD) liquid signal
To date, despite much effort to improve the image quality of MRCP, some questions still remain unanswered; it is unknown whether there is a variability in Mn2+ content in PJ of the same commercially available brand produced in different years
The concentrations of M n2+ in PJ of the same commercially available brand produced in different years, redefined using Atomic Absorption Spectrometry (AAS), did not demonstrate any difference

Summary

Introduction

To evaluate the potential variability of Manganese (Mn2+) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn2+ concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress the gastroduodenal (GD) liquid signal. Several oral negative contrast agents, containing paramagnetic substances which shorten the T2 relaxation time, reducing the signal hyperintensity of gastro-enteric fluids in standard MRCP sequences, have been produced by pharmaceutical companies and have been utilised in daily radiological practice in the past in order to overcome this limitation[6,7]. These negative oral contrast agents have many limitations; they are relatively unpalatable, are too diluted in the gastrointestinal tract or are too e xpensive[6]. In more recent years, natural fruit juices have gained attention, the most popular being pineapple juice (PJ) and blueberry juice, owing to their properties which are similar to pharmaceutical oral negative contrast agents, having the same ability to suppress the high signal from gastrointestinal tract liquids on MRCP, but without the described limitations, having good palatability and a lower cost

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