Abstract
The study of biologically active substances-secondary metabolites of plants that exhibit geroprotective properties is an actual and popular direction in medicine to prevent early aging. This work aims to select the cultivation parameters for obtaining in vitro cell cultures of meadowsweet containing the largest amount of biologically active substances (BAS) for their further extraction as candidate substances for geroprotectors. To specify the effectiveness of the selected cell culture cultivation parameters, biomass growth for callus and root cultures, growth index, specific growth rate, and viability for suspension cultures was carried out. The study results made it possible to select the nutrient media for the cultivation of cell cultures of meadowsweet. It has been found that the greater the antioxidant activity of the extracts, the greater the antimicrobial properties it exhibits. In this study, cell cultures in vitro and alcohol extracts from the plant Filipendula ulmaria were considered as raw materials rich in candidate substances for geroprotectors. According to the data obtained, the plant is rich in hydroxybenzoic and salicylic acids, spireoside, avicularin, and hyperoside.
Highlights
Aging is a complex process that influences all systems of the body (molecular, cellular, tissue, etc. (Ito et al, 2012; Moskalev et al, 2017)
Suspension cultures were grown on nutrient media, the composition of which is shown in Table 3. [Table 3] - In vitro root cultures of meadowsweet were obtained from sterile seedlings of plant seeds, namely, from the leaves obtained at the 1st stage of this work
Cell cultures in vitro and alcohol extracts from the plant Filipendula ulmaria were considered as raw materials rich in candidate substances for geroprotectors
Summary
Aging is a complex process that influences all systems of the body (molecular, cellular, tissue, etc. (Ito et al, 2012; Moskalev et al, 2017). (Ito et al, 2012; Moskalev et al, 2017) This process is accompanied by a number of chronic diseases Geroprotectors are pharmacological substances that can slow down the. Moskalev and his colleagues presented a number of criteria that candidate substances should meet for geroprotectors (Moskalev et al, 2017): 1. Moskalev and his colleagues presented a number of criteria that candidate substances should meet for geroprotectors (Moskalev et al, 2017): 1. The possibility of increasing the duration and quality of life
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