Optimization of MNPs by size fractionation for MPI application

Abstract

Magnetic iron oxide nanoparticles are numbered among the most suitable tracer materials for Magnetic Particle Imaging (MPI) since they feature the potential of high signal intensities while simultaneously being well tolerated in vivo. To tap the full potential of this innovative imaging modality, magnetic nanoparticles (MNPs) with tailored magnetic properties are required. To achieve such tailoring, an understanding of the relation between particle structure and the resulting MPI performance is most desirable. In this work, we present the effect of the MPI efficacy of in-house synthesized MNPs in dependence of their hydrodynamic diameter.