Abstract
The synthesis process or composition of mesoporous silica nanoparticles (MSNs) affects the physicochemical properties. Using these properties, MSNs were synthesized through the Box–Behnken design (BBD) among statistical experimental methods. The effect of the amounts of synthetic reagents, hexadecyl triethyl ammonium bromide (CTAB), tetraethyl orthosilicate (TEOS), and 2 N sodium hydroxide (NaOH), was studied using the reaction surface design. Surface area, particle size, and zeta potential were set as response values. The physicochemical properties of the optimized MSNs were evaluated, and the effect as a drug delivery system was evaluated by loading doxorubicin hydrochloride (DOX). Nano-sized MSNs were successfully prepared with 0.617 g of CTAB, 8.417 mL of TEOS, and 2.726 mL of 2 N NaOH and showed excellent physicochemical properties. The optimized MSNs showed negligible toxicity in MCF-7 cells. The drug release profile from DOX-loaded MSNs (MSN@DOX) showed an increased rate of release with decreasing pH of the medium, with the release profile sustained for 48 h. In the cytotoxicity test, the sustained drug release mechanism of MSN@DOX was confirmed. This study proposed a new statistical approach to the synthesis of MSNs.
Highlights
The structure ordering was determined through the presence or absence of particle formation and the small angle X-ray diffraction (SAXRD) pattern (Figure 1)
CTAB was used as the template for micelle formation during mesoporous silica nanoparticles (MSNs) synthesis [27]
White powder was formed in MSNs (F1, F2, F3, F4, and F5) using various amounts of CTAB
Summary
In the early 1990s, a new silica-based material called mesoporous silica was discovered. Mesoporous silica nanoparticles (MSNs) such as MCM-41, MCM-48, and SBA-15 with pore size of 2–10 nm, and 2D hexagonal and 3D cube structural properties have attracted great attention in various fields [1]. MSNs are actively being studied in the field of biomedicine, especially drug delivery systems [2,3]. MSNs have become the next-generation inorganic material platform for biomedical applications [4,5,6]. MSNs are being actively studied in the field of drug delivery systems due to their unique mesostructural properties such as large surface area, large pore volume, adjustable particle size, easy surface functionalization, Pharmaceutics 2021, 13, 184.
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