Abstract
Mechanochemical-assisted extraction (MCAE) of hesperidin from Pericarpium Citri Reticulatae was investigated in AGO-2 high intensity planetary activator. In order to optimize extraction efficiency, six variables (different kinds of reagents, Na2CO3 content, grinding time, extraction temperature, extraction time, liquid/solid ratio) were varied. Results showed that the optimum MCAE conditions were determined as: Na2CO3 content of 30.0% (w/w), grinding time 20 min, extraction temperature 20 °C, extraction time 10 min, liquid/solid ratio of 80:1 mL/g. Meanwhile, enhancement of solubility was measured. Fourier transform-infrared spectrometer and scanning electron microscope were used to illustrate structure change of hesperidin after mechanochemical pretreatment. With the optimized parameter settings, MCAE with water as solvent gave the highest hesperidin yield while reducing both extraction time and energy costs compared to the heat-reflux and superfine grinding extraction.
Highlights
Pericarpium Citri Reticulatae (PCR) has been widely used as in foods and medicines for a long time because of good activity, rich resources, low toxicity and costs (Wang et al, 2008)
The results showed that Na2CO3 exhibited the highest extraction yield (p < 0.05) under the same extraction condition, which will form an insoluble chelate of calcium with hesperidin after mechanical activation
The mechanochemicalassisted extraction (MCAE) process defined in this study increased (p
Summary
Pericarpium Citri Reticulatae (PCR) has been widely used as in foods and medicines for a long time because of good activity, rich resources, low toxicity and costs (Wang et al, 2008). The drawbacks of traditional technology to extract hesperidin include the use of toxic and flammable organic solvent, the low extraction yield in single treatment step, increased production losses, and environmental contamination (Korolev et al, 2003). The novel application of mechanochemicalassisted extraction (MCAE) technology in vegetable materials extraction processing attracts wide attentions. It has improved extraction yield of triterpene acids from fir needles by 35.9% (Korolev et al, 2003). Impact-shearing on the particles of the processed material is accompanied by destruction of the cell wall. This significantly facilitates the isolation of the components in the processed material. The extraction time is reduced significantly because of mechanicochemical treatment increase the effective surface area of the mixture components
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