Abstract
Optimization of ionic liquid-based microwave-assisted extraction on brazilin levels from sappan wood and its dipeptidyl peptidase IV inhibition activity
Highlights
The application of green chemistry on the selection of solvents has increased to explore the content and potential effect of active compounds from natural sources
Brazilin levels were determined by the high performance liquid chromatography (HPLC) gradient method (0.3% acetic acid in water and acetonitrile)
The materials used in this study, including sappan wood (C. sappan), were purchased from Bogor Botanical Garden and identified n Indonesia Institute of Sciences (LIPI) Bogor. 1-butyl-3 methyl imidazolium bromide ([BMIM]Br), 1-butyl-3-methyl imidazolium tetrafluoroborate ([BIMI]BF4), and 1-butyl-3-methyl imidazolium hexafluorophosphate
Summary
The application of green chemistry on the selection of solvents has increased to explore the content and potential effect of active compounds from natural sources. Ionic liquid (IL) was discovered as an option to replace organic solvents (Espino et al, 2016). IL is a pure salt compound containing ionic components (cation and anion), which melts at a temperature below 100°C (Tan et al, 2016). Microwave-assisted extraction (MAE) is widely used to replace conventional extraction methods used to use volatile organic solvents such as methanol, ethanol, hexane, and ethyl acetate. The advantages of MAE compared to conventional extraction methods are easy to use, fast, efficient, effective, good selectivity, and inexpensive (Ballard et al, 2010; Du et al, 2007). The application of the microwave extraction method has been
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