Optimization of hydrogel composition for effective release of drug

Abstract

Abstract Hydrogels are possible materials that could be useful in medication delivery systems. Diverse release mechanisms are used when drug molecules embedded in the hydrogel structure need to be released. Both case I and case II of transport refer to the release of the medication during the intermolecular arrangement because of swelling. Numerous mathematical models have been proposed that only include one form of transport; nevertheless, both transport pathways are required for the entire release of a drug from a gel matrix. The case I transport during swelling and the case II transport during the fully swollen condition are both displayed by crosslinked hyaluronic acid hydrogel systems. The methodology put out in this paper enables for the selection of suitable gel compositions while attempting to account for both transit instances. In the Data Envelopment Analysis coupled with principal component analysis approaches are enable the optimization and selection of gel compositions that account for both transport situations.