Abstract
Objective. To review the pharmacokinetics profile of (HD-BU) high-dose busulfan, review published phar macodynamic relationships of high-dose busulfan and discuss clinical considerations of monitoring patients receiving high-dose busulfan.Data Sources. A MEDLINE search of articles published from 1985 to 1996 and a Cancerlit search of articles published from 1988 to 1996, using the Mesh headings (subheading: pharmacokinetics), Bone Marrow Transplantation and Hepatic Veno occlusive Disease.Study Selection. All human trials evaluating the pharmacokinetic profile and the pharmacodynamic relationships of high-dose busulfan in bone marrow transplant patients.Data Synthesis. Busulfan disposition has been extensively studied in both children and adults receiv ing high doses followed by stem cell rescue. Sample sizes ranged from 7 to 28 patients, with patients ranging from 0.3 to 60 years of age. Busulfan total doses ranged from 14 mg/kg to 640 mg/m2. A large interpatient variability has been report...
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